Ectopia lentis

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Ectopia lentis
Ectopia Lentis in Marfan syndrome.jpg
Synonyms Lens dislocation, lens subluxation
Pronounce N/A
Specialty N/A
Symptoms Blurred vision, double vision, visual distortion
Complications Retinal detachment, glaucoma, cataract
Onset Can be congenital or acquired
Duration Chronic
Types N/A
Causes Genetic disorders, trauma, homocystinuria, Marfan syndrome, Ehlers-Danlos syndrome
Risks Family history, connective tissue disorders
Diagnosis Slit lamp examination, ultrasound biomicroscopy, genetic testing
Differential diagnosis Keratoconus, cataract, retinal detachment
Prevention N/A
Treatment Corrective lenses, surgery
Medication None specific, but may include eye drops for associated conditions
Prognosis Variable, depending on underlying cause and treatment
Frequency Rare
Deaths Not directly fatal


Ectopia lentis is a rare, hereditary disorder that affects the eyes, specifically the lens. The lens is a clear structure in the eye that helps to focus light on the retina. In people with ectopia lentis, the lens is displaced or malpositioned. This displacement can occur in any direction and can vary in severity. Ectopia lentis can be an isolated condition or it can be associated with other systemic disorders such as Marfan syndrome or Homocystinuria.

Causes[edit | edit source]

Ectopia lentis is usually caused by a mutation in the FBN1 gene. This gene provides instructions for making a protein called fibrillin-1. Fibrillin-1 is an important component of the connective tissue that provides strength and flexibility to many structures in the body. When the FBN1 gene is mutated, it can lead to the production of abnormal fibrillin-1 protein, which can cause the lens to become dislocated.

Symptoms[edit | edit source]

The symptoms of ectopia lentis can vary greatly from person to person. Some people may have no symptoms at all, while others may experience severe vision problems. Common symptoms include:

Diagnosis[edit | edit source]

Ectopia lentis is typically diagnosed through a comprehensive eye examination. This may include a Slit lamp examination, which allows the doctor to examine the structures at the front of the eye under magnification. Genetic testing may also be performed to confirm the diagnosis and identify any associated systemic disorders.

Treatment[edit | edit source]

Treatment for ectopia lentis depends on the severity of the condition and the presence of any associated disorders. In mild cases, corrective lenses may be sufficient to improve vision. In more severe cases, surgery may be required to reposition or replace the dislocated lens.

Ectopia_lentis gallery[edit | edit source]

See also[edit | edit source]

References[edit | edit source]

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Contributors: Prab R. Tumpati, MD