Lercanidipine
Lercanidipine is a calcium channel blocker of the dihydropyridine class, specifically designed to treat hypertension. It is marketed under various trade names.
Etymology[edit | edit source]
The name "Lercanidipine" is derived from the chemical structure of the drug, which is a dihydropyridine calcium antagonist. The prefix "Ler-" is derived from the name of the company that first synthesized the drug, Recordati's Lercanidipine.
Pharmacology[edit | edit source]
Lercanidipine inhibits the influx of calcium ions through L-type calcium channels in the cell membrane, reducing the amount of calcium available for smooth muscle contraction. This results in vasodilation and a reduction in blood pressure.
Clinical Use[edit | edit source]
Lercanidipine is used primarily for the treatment of hypertension. It is typically administered once daily, with the dose adjusted according to the patient's response and tolerance. The drug is well tolerated, with the most common side effects being headache, dizziness, and flushing.
Contraindications[edit | edit source]
Lercanidipine is contraindicated in patients with known hypersensitivity to dihydropyridines, severe hepatic impairment, and in patients with unstable angina or within one month of a myocardial infarction.
Interactions[edit | edit source]
Lercanidipine may interact with other drugs, including beta blockers, digoxin, warfarin, and cimetidine. It is also known to interact with grapefruit juice, which can increase the concentration of the drug in the bloodstream and enhance its effects.
Related Terms[edit | edit source]
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Contributors: Prab R. Tumpati, MD
