Leukoencephalopathy

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Overview[edit | edit source]

Leukoencephalopathy refers to a group of disorders characterized by the degeneration of the white matter in the brain. The term is derived from "leuko," meaning white, and "encephalopathy," meaning brain disease. These disorders can be caused by a variety of factors, including genetic mutations, infections, and exposure to toxic substances.

MRI image showing leukoencephalopathy

Causes[edit | edit source]

Leukoencephalopathy can result from several different causes:

Symptoms[edit | edit source]

The symptoms of leukoencephalopathy vary depending on the underlying cause and the extent of white matter damage. Common symptoms include:

  • Cognitive decline
  • Motor dysfunction
  • Behavioral changes
  • Seizures
  • Visual disturbances

Diagnosis[edit | edit source]

Diagnosis of leukoencephalopathy typically involves:

  • Magnetic Resonance Imaging (MRI): MRI is the primary tool used to visualize changes in the white matter.
  • Genetic Testing: For hereditary forms, genetic testing can identify specific mutations.
  • Blood Tests: These can help rule out infectious causes or metabolic disorders.

Treatment[edit | edit source]

Treatment for leukoencephalopathy depends on the underlying cause:

  • Genetic Disorders: Management may involve supportive care and, in some cases, bone marrow transplantation.
  • Infections: Antiviral medications may be used for viral causes like PML.
  • Toxic Exposure: Discontinuation of the offending agent and supportive care.

Prognosis[edit | edit source]

The prognosis for individuals with leukoencephalopathy varies widely. Some forms, particularly those that are genetic, may have a progressive course, while others may stabilize with treatment.

Related pages[edit | edit source]

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Contributors: Prab R. Tumpati, MD