Levodropropizine

Levodropropizine is a non-opioid antitussive agent, used primarily for the treatment of cough. It is an antagonist of the histamine H1 receptor and an inhibitor of the tachykinin NK1 receptor. Levodropropizine is marketed under various brand names worldwide.

Pharmacology

Levodropropizine works by reducing the activity of the cough reflex and reducing the need to cough. It is considered a peripheral antitussive, as it does not act on the central nervous system but on the sensory nerve endings in the respiratory tract.

Clinical Use

Levodropropizine is used for the treatment of productive and non-productive cough. It is often used when the cough is not being controlled by other treatments, or when other treatments are not suitable. It is typically administered in syrup form.

Side Effects

Common side effects of Levodropropizine include gastrointestinal disturbances, headache, dizziness, and rash. In rare cases, it can cause hypersensitivity reactions.

Contraindications

Levodropropizine is contraindicated in patients with known hypersensitivity to the drug or any of its components. It should be used with caution in patients with severe liver disease or kidney disease.

Interactions

Levodropropizine may interact with other drugs that depress the central nervous system, including alcohol, barbiturates, and benzodiazepines.