Ligneous conjunctivitis

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Ligneous conjunctivitis
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Synonyms Conjunctivitis lignosa[1]
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Field ophthalmology
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Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva).[2] It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia.[3] It can be sight-threatening,[3] and death can occasionally occur from pulmonary involvement. [citation needed]


It has been speculated hola ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva.[4]

Pathogenesis[edit | edit source]

Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency in plasmin-mediated extracellular fibrinolysis.[2] Episodes may be triggered by minor trauma, eye surgery, or by systemic events such as infections or antifibrinolytic therapy.[3] Histology shows amorphous subepithelial deposits of eosinophilic material consisting predominantly of fibrin. [clarification needed]


Diagnosis[edit | edit source]


Treatment[edit | edit source]

Ligneous conjunctivitis may be managed by topical treatments of plasminogen,[2] topical and subconjunctival fresh frozen plasma,[2] and fibrinolytic therapy.[5]

References[edit | edit source]

  1. ↑ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Ligneous conjunctivitis". www.orpha.net. Retrieved 26 June 2019.{{cite web}}: CS1 maint: numeric names: authors list (link)
  2. ↑ 2.0 2.1 2.2 2.3
  3. ↑ 3.0 3.1 3.2 "Ligneous conjunctivitis". Orphanet. Retrieved July 21, 2012.
  4. ↑
  5. ↑ "Ligneous Conjunctivitis". Ocular Pathology. Retrieved July 21, 2012.

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Contributors: Prab R. Tumpati, MD