Ligneous conjunctivitis
Ligneous conjunctivitis is a rare form of chronic conjunctivitis characterized by recurrent, fibrin-rich pseudomembranous lesions of wood-like consistency that develop mainly on the underside of the eyelid (tarsal conjunctiva).[1] It is generally a systemic disease which may involve the periodontal tissue, the upper and lower respiratory tract, kidneys, middle ear, and female genitalia.[2] It can be sight-threatening,[2] and death can occasionally occur from pulmonary involvement.
[citation needed]
It has been speculated hola ligneous conjunctivitis may be a manifestation of IgG4-related disease (IgG4-RD) involving the conjunctiva.[3]
Pathogenesis[edit | edit source]
Histopathological findings from affected humans indicate that wound healing is impaired due to a deficiency in plasmin-mediated extracellular fibrinolysis.[1] Episodes may be triggered by minor trauma, eye surgery, or by systemic events such as infections or antifibrinolytic therapy.[2] Histology shows amorphous subepithelial deposits of eosinophilic material consisting predominantly of fibrin. [clarification needed]
Diagnosis[edit | edit source]
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Treatment[edit | edit source]
Ligneous conjunctivitis may be managed by topical treatments of plasminogen,[1] topical and subconjunctival fresh frozen plasma,[1] and fibrinolytic therapy.[4]
References[edit | edit source]
External links[edit | edit source]
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- Articles with unsourced statements from July 2012
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- Disorders of conjunctiva
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- IgG4-related disease
- Medical dictionary
Contributors: Prab R. Tumpati, MD
