Linsitinib
Linsitinib is an experimental drug candidate for the treatment of various types of cancer. It is an inhibitor of the insulin receptor and of the insulin-like growth factor 1 receptor (IGF-1R).[1] This prevents tumor cell proliferation and induces tumor cell apoptosis.[2]
Linsitinib was granted orphan drug designation for adrenocortical carcinoma in March 2012.[3]
Phase II clinical trials were initiated for multiple myeloma, ovarian cancer, hepatocellular carcinoma, and NSCLC, but subsatisfactory results caused research for these indications to be discontinued.[3] A phase III clinical trial found that linsitinib did not increase survival in patients with adrenocortical carcinoma.[4] As of 2017, no clinical trials were in progress.[3]
References[edit | edit source]
- ↑
- ↑ "Linsitinib". NCI Drug Dictionary. National Cancer Institute. Retrieved October 16, 2012.
- ↑ 3.0 3.1 3.2 "Linsitinib - AdisInsight". adisinsight.springer.com.
- ↑
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