Liranaftate
Liranaftate is an antifungal medication used in the treatment of various skin infections caused by fungi. It is a topical agent, applied directly to the skin, and is available in various forms such as creams and powders. Liranaftate is known for its broad-spectrum antifungal activity and its ability to penetrate the stratum corneum effectively.
Mechanism of Action[edit | edit source]
Liranaftate works by inhibiting the enzyme squalene epoxidase, which is essential for the synthesis of ergosterol. Ergosterol is a vital component of the fungal cell membrane. By inhibiting its production, liranaftate disrupts the integrity of the cell membrane, leading to the death of the fungal cell.
Uses[edit | edit source]
Liranaftate is primarily used in the treatment of tinea pedis (athlete's foot), tinea cruris (jock itch), and tinea corporis (ringworm). It is also effective against Candida species and Malassezia furfur, which are responsible for conditions such as pityriasis versicolor.
Side Effects[edit | edit source]
Common side effects of liranaftate include skin irritation, burning, and redness at the application site. Severe allergic reactions are rare but can occur.
Pharmacokinetics[edit | edit source]
Liranaftate is poorly absorbed through the skin, which allows it to remain in the skin and exert its antifungal effects. It is metabolized in the liver and excreted in the urine and feces.
History[edit | edit source]
Liranaftate was first developed in Japan and has been available there since 1993. It is currently marketed in various countries around the world.
See Also[edit | edit source]
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Contributors: Prab R. Tumpati, MD