Lisofylline

Lisofylline (LSF) is a synthetic chemical compound with potential anti-inflammatory and immunomodulatory effects. It is an inhibitor of phosphatidic acid (PA) and lysophosphatidic acid (LPA) production, which are key components in the inflammatory response and cell proliferation.

Chemistry

Lisofylline is a derivative of Pentoxifylline, a xanthine derivative. It is a white to off-white crystalline powder that is soluble in water and ethanol. The chemical name for Lisofylline is 1-(5-oxohexyl)-3,7-dimethylxanthine.

Pharmacology

Lisofylline acts by inhibiting the production of phosphatidic acid (PA) and lysophosphatidic acid (LPA), which are involved in the inflammatory response and cell proliferation. By inhibiting these substances, Lisofylline can potentially reduce inflammation and modulate the immune response.

Clinical Uses

Lisofylline has been investigated for use in a variety of conditions, including acute lung injury, acute respiratory distress syndrome (ARDS), cystic fibrosis, and Type 1 diabetes. It has also been studied for its potential to reduce the side effects of certain cancer treatments.

Side Effects

As with any drug, Lisofylline may cause side effects. These can include nausea, vomiting, and diarrhea. More serious side effects can include liver damage and allergic reactions.

Research

Research into the potential uses of Lisofylline is ongoing. It has shown promise in preclinical studies for its anti-inflammatory and immunomodulatory effects, and clinical trials are underway to further investigate these potential benefits.

See Also

• Phosphatidic acid
• Lysophosphatidic acid
• Pentoxifylline
• Acute lung injury
• Acute respiratory distress syndrome
• Cystic fibrosis
• Type 1 diabetes

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