List of benzimidazole opioids

List of benzimidazole opioids

Benzimidazole Opioids

Benzimidazole opioids are a class of synthetic opioids that are structurally related to the benzimidazole chemical structure. These compounds are known for their potent analgesic effects and are often used in research settings to study opioid receptor interactions. The benzimidazole opioids are of particular interest due to their high affinity for the mu-opioid receptor, which is the primary target for opioid analgesics.

General structure of nitazenes

General Characteristics

Benzimidazole opioids typically feature a benzimidazole core structure, which is a bicyclic compound consisting of a benzene ring fused to an imidazole ring. This core structure is modified with various substituents to produce different compounds with varying pharmacological properties. The modifications can affect the potency, duration of action, and receptor selectivity of the opioids.

List of Benzimidazole Opioids

The following is a list of notable benzimidazole opioids, each with unique chemical structures and pharmacological profiles:

Nitazenes

Nitazenes are a subclass of benzimidazole opioids that have gained attention for their potent analgesic properties. They are characterized by the presence of a nitro group on the benzimidazole ring.

• Isotonitazene
• Metonitazene
• Protonitazene

Structure of DEAE-BN-BI

Etazenes

Etazenes are another subclass of benzimidazole opioids, known for their high potency and efficacy at the mu-opioid receptor.

• Etazene

Error creating thumbnail:

Structure of Etazene

Metodesnitazenes

Metodesnitazenes are derivatives of nitazenes with modifications that enhance their pharmacological activity.

• Metodesnitazene

Structure of Metodesnitazene

Pyrrolidine Etodesnitazenes

These compounds are characterized by the addition of a pyrrolidine ring, which can alter their interaction with opioid receptors.

• Pyrrolidine Etodesnitazene

Structure of Pyrrolidine Etodesnitazene

Metodesnitazepynes

Metodesnitazepynes are a unique subclass with a distinct chemical structure that includes a pyrazine ring.

• Metodesnitazepyne

Error creating thumbnail:

Structure of Metodesnitazepyne

Pharmacology

Benzimidazole opioids primarily act as agonists at the mu-opioid receptor, which is responsible for their analgesic effects. They may also interact with other opioid receptors, such as the delta and kappa receptors, contributing to their overall pharmacological profile. The potency and efficacy of these compounds can vary significantly, with some being several times more potent than morphine.

Safety and Legal Status

Due to their high potency and potential for abuse, many benzimidazole opioids are controlled substances in various jurisdictions. Their use is typically restricted to research settings, and they are not approved for medical use in humans.

Related Pages

• Opioid
• Mu-opioid receptor
• Analgesic