List of estrogens

The List of estrogens]] includes natural, synthetic, and pharmaceutical compounds that are classified as estrogens. Estrogens are a group of steroid hormones that play an essential role in the regulation of the reproductive system, as well as in the development and maintenance of secondary sexual characteristics in females. They are also present in males, where they play a role in the reproductive system and bone health. This list encompasses a variety of estrogens with different sources, chemical structures, and functions.

Natural Estrogens

Natural estrogens are compounds that occur naturally and play a vital role in the body's endocrine system. The primary natural estrogens include:

• Estradiol – the most potent and prevalent form of estrogen in premenopausal females.
• Estrone – a weaker form of estrogen, which becomes more prevalent after menopause.
• Estriol – the weakest of the primary estrogens, which is present in significant amounts during pregnancy.

Synthetic Estrogens

Synthetic estrogens are man-made compounds designed to mimic the activity of natural estrogens. They are often used in hormone replacement therapy (HRT) and contraceptives. Examples include:

• Ethinylestradiol – a highly potent estrogen used in many oral contraceptives.
• Mestranol – a synthetic estrogen used in some of the first oral contraceptives; it is a prodrug of ethinylestradiol.

Pharmaceutical Estrogens

Pharmaceutical estrogens are estrogens that are manufactured for medical use. They can be either natural or synthetic. Examples include:

• Conjugated estrogens – a mixture of estrogens obtained from natural sources, used in hormone replacement therapy.
• Estrogen esters – estrogens chemically linked to an ester to prolong their action when used in therapy, such as estradiol valerate and estradiol cypionate.

Selective Estrogen Receptor Modulators (SERMs)

Selective Estrogen Receptor Modulators (SERMs) are a class of drugs that act on the estrogen receptor. They can mimic or block estrogen's effects in various tissues. Examples include:

• Tamoxifen – used in the treatment and prevention of breast cancer.
• Raloxifene – used to prevent osteoporosis in postmenopausal women.

Estrogen Antagonists

Estrogen antagonists, also known as antiestrogens, block the effects of estrogen in the body. They are used primarily in the treatment of hormone-sensitive cancers. Examples include:

• Fulvestrant – a pure estrogen receptor antagonist used in the treatment of hormone receptor-positive metastatic breast cancer.

See also

• Endocrine system
• Hormone replacement therapy
• Sexual characteristics
• Steroid hormone

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