Lobucavir

From WikiMD.com - Food, Medicine & Wellness Encyclopedia

An antiviral drug candidate


Lobucavir
INN
Drug class
Routes of administration
Pregnancy category
Bioavailability
Metabolism
Elimination half-life
Excretion
Legal status
CAS Number
PubChem
DrugBank
ChemSpider
KEGG


Lobucavir is an antiviral drug that was developed for the treatment of various viral infections. It is a nucleoside analogue that inhibits viral DNA polymerase, thereby preventing viral replication.

Mechanism of Action[edit | edit source]

Lobucavir functions as a nucleoside analogue, which means it mimics the natural building blocks of DNA. When incorporated into viral DNA by the viral DNA polymerase, it causes premature chain termination. This effectively halts the replication of the virus, as the incomplete DNA cannot be used to produce new viral particles.

Development and Clinical Trials[edit | edit source]

Lobucavir was initially developed for the treatment of hepatitis B virus (HBV) and herpes simplex virus (HSV) infections. During its development, it showed promise in inhibiting the replication of these viruses in vitro and in early clinical trials.

Hepatitis B Virus[edit | edit source]

In studies involving patients with chronic hepatitis B, lobucavir demonstrated a reduction in viral load and improvement in liver function tests. However, further development was halted due to concerns about potential carcinogenicity observed in animal studies.

Herpes Simplex Virus[edit | edit source]

Lobucavir was also tested for efficacy against herpes simplex virus infections. It showed activity against both HSV-1 and HSV-2 in laboratory settings. Despite these promising results, the development for this indication was also discontinued.

Chemical Structure[edit | edit source]

Chemical structure of Lobucavir

Lobucavir is a synthetic analogue of the natural nucleoside guanosine. Its chemical structure allows it to be incorporated into viral DNA, where it acts as a chain terminator.

Potential Uses[edit | edit source]

Although lobucavir is not currently approved for clinical use, its mechanism of action suggests potential applications in treating other DNA virus infections. Research into similar compounds continues, with the aim of developing safer and more effective antiviral therapies.

Related Pages[edit | edit source]

WikiMD
Navigation: Wellness - Encyclopedia - Health topics - Disease Index‏‎ - Drugs - World Directory - Gray's Anatomy - Keto diet - Recipes

Search WikiMD

Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD

WikiMD's Wellness Encyclopedia

Let Food Be Thy Medicine
Medicine Thy Food - Hippocrates

Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates, categories Wikipedia, licensed under CC BY SA or similar.

Contributors: Prab R. Tumpati, MD