Nucleoside analogue

Nucleoside analogues are a group of antiviral or anticancer drugs. They are the mainstay of treatment for HIV/AIDS, hepatitis B, hepatitis C, and cancer.

Mechanism of action

Nucleoside analogues work by disrupting the DNA or RNA replication process of the virus or cancer cell. They are structurally similar to the normal nucleosides needed for DNA and RNA synthesis. When these analogues are incorporated into the DNA or RNA, it results in premature termination of the chain, thus inhibiting the replication of the virus or cancer cell.

Types of Nucleoside Analogues

There are several types of nucleoside analogues, including:

• Adenosine analogue
• Cytidine analogue
• Guanosine analogue
• Thymidine analogue
• Uridine analogue

Each of these analogues targets a specific type of virus or cancer cell.

Side Effects

Like all drugs, nucleoside analogues can have side effects. These can include:

• Nausea
• Vomiting
• Diarrhea
• Fatigue
• Anemia
• Neutropenia

See Also

• Antiviral drug
• Anticancer drug
• DNA replication
• RNA replication

References

Nucleoside analogue Resources
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