Lofentanil

Lofentanil is a potent opioid analgesic drug that is an analogue of fentanyl. It is most commonly used in veterinary medicine, although it is also used in human medicine under certain circumstances. Lofentanil is one of the most potent opioids available, with a potency some 4,000-6,000 times that of morphine.

Pharmacology

Lofentanil acts on the mu opioid receptors in the brain and spinal cord, producing analgesia and sedation. Like other opioids, it can cause respiratory depression, and its use is therefore carefully monitored.

Medical uses

In human medicine, lofentanil is used for the induction of general anesthesia in patients who are at high risk of adverse reactions to other anesthetics. It is also used for pain management in patients with severe chronic pain who are tolerant to other opioids.

In veterinary medicine, lofentanil is used for the immobilization and anesthesia of large animals, such as elephants and rhinoceroses.

Side effects

The side effects of lofentanil are similar to those of other opioids and include respiratory depression, nausea, vomiting, and constipation. It can also cause dependence and withdrawal symptoms if used for prolonged periods.

See also

• Fentanyl
• Opioid
• General anesthesia

References

Lofentanil Resources
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