Long-chain fatty acid transport protein 1
Long-chain fatty acid transport protein 1 (LCFATP1), also known as solute carrier family 27 member 1 (SLC27A1), is a protein that in humans is encoded by the SLC27A1 gene. This protein is a member of the fatty acid transport protein (FATP) family, which is involved in the uptake and metabolism of fatty acids.
Function[edit | edit source]
LCFATP1 is an integral membrane protein primarily located in the plasma membrane and mitochondria. It plays a crucial role in the transport of long-chain fatty acids into cells, which are essential for various cellular processes, including energy production, lipid metabolism, and cell signaling.
Structure[edit | edit source]
The SLC27A1 gene is located on the chromosome 19 (19q13.43) and spans approximately 20 kilobases. The protein encoded by this gene has a molecular weight of approximately 71 kDa and consists of 620 amino acids. It contains a conserved ATP/AMP signature motif, which is characteristic of the FATP family.
Clinical significance[edit | edit source]
Mutations in the SLC27A1 gene have been associated with various diseases, including Ichthyosis and neutral lipid storage disease with myopathy (NLSDM). Further research is needed to fully understand the role of LCFATP1 in these conditions.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
Medical Disclaimer: WikiMD is not a substitute for professional medical advice. The information on WikiMD is provided as an information resource only, may be incorrect, outdated or misleading, and is not to be used or relied on for any diagnostic or treatment purposes. Please consult your health care provider before making any healthcare decisions or for guidance about a specific medical condition. WikiMD expressly disclaims responsibility, and shall have no liability, for any damages, loss, injury, or liability whatsoever suffered as a result of your reliance on the information contained in this site. By visiting this site you agree to the foregoing terms and conditions, which may from time to time be changed or supplemented by WikiMD. If you do not agree to the foregoing terms and conditions, you should not enter or use this site. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD