Long-chain fatty acid transport protein 1

Long-chain fatty acid transport protein 1 (LCFATP1), also known as solute carrier family 27 member 1 (SLC27A1), is a protein that in humans is encoded by the SLC27A1 gene. This protein is a member of the fatty acid transport protein (FATP) family, which is involved in the uptake and metabolism of fatty acids.

Function

LCFATP1 is an integral membrane protein primarily located in the plasma membrane and mitochondria. It plays a crucial role in the transport of long-chain fatty acids into cells, which are essential for various cellular processes, including energy production, lipid metabolism, and cell signaling.

Structure

The SLC27A1 gene is located on the chromosome 19 (19q13.43) and spans approximately 20 kilobases. The protein encoded by this gene has a molecular weight of approximately 71 kDa and consists of 620 amino acids. It contains a conserved ATP/AMP signature motif, which is characteristic of the FATP family.

Clinical significance

Mutations in the SLC27A1 gene have been associated with various diseases, including Ichthyosis and neutral lipid storage disease with myopathy (NLSDM). Further research is needed to fully understand the role of LCFATP1 in these conditions.

See also

• Fatty acid transport protein
• Solute carrier family