Lymphoblasts

Lymphoblasts are immature cells which typically differentiate to form mature lymphocytes. These cells are found in the bone marrow and are an essential part of the immune system. Lymphoblasts are involved in the body's response to infection and disease.

Overview

Lymphoblasts are the earliest form of lymphocytes, which are a type of white blood cell. They are produced in the bone marrow from stem cells and undergo a process of differentiation to become either B cells, T cells, or natural killer cells. These mature lymphocytes play a crucial role in the body's immune response.

Differentiation

The differentiation of lymphoblasts into mature lymphocytes is a complex process that is regulated by various growth factors and cytokines. This process involves a series of changes in the cell's morphology, gene expression, and function. The resulting lymphocytes are then released into the bloodstream where they can respond to foreign substances such as bacteria and viruses.

Clinical Significance

Abnormalities in the number or function of lymphoblasts can lead to various health conditions. For example, an excessive number of lymphoblasts in the blood is a characteristic feature of acute lymphoblastic leukemia (ALL), a type of cancer that primarily affects children. On the other hand, a deficiency of lymphoblasts can result in a weakened immune response, making the individual more susceptible to infections.

See Also

• Hematopoiesis
• Leukemia
• Immune system
• White blood cell