MAGEA2

Ideogram human chromosome X

MAGEA2

MAGEA2 is a gene that encodes a member of the MAGEA family of cancer-testis antigens. These antigens are normally expressed in male germ cells but are also found in various cancers. The MAGEA2 gene is located on chromosome Xq28 and plays a role in oncogenesis.

Function

The protein encoded by MAGEA2 is a tumor-specific antigen that is involved in the development and progression of cancer. It is thought to play a role in immune evasion by cancer cells and may be a potential target for cancer immunotherapy.

Clinical Significance

MAGEA2 expression has been detected in a variety of cancers, including melanoma, lung cancer, and bladder cancer. High levels of MAGEA2 expression have been associated with poor prognosis in some cancer types, making it a potential biomarker for disease progression.

Therapeutic Target

Due to its tumor-specific expression and role in cancer development, MAGEA2 has been investigated as a potential target for cancer therapy. Targeting MAGEA2 with immunotherapies, such as cancer vaccines or adoptive T-cell therapy, may offer a promising approach for treating MAGEA2-positive cancers.

See also

• Cancer-testis antigen
• Immunotherapy
• Tumor antigen