MALT

Mucosa-associated lymphoid tissue (MALT) is a diffuse system of small concentrations of lymphoid tissue found in various submucosal membrane sites of the body, such as the gastrointestinal tract, nasopharynx, thyroid, breast, lung, salivary glands, eye, and skin. MALT is populated by lymphocytes such as T cells and B cells, as well as plasma cells and macrophages, each of which is well situated to encounter antigens passing through the mucosal epithelium.

Structure

MALT is a component of the lymphatic system and is formed from loose connective tissue. It contains lymphocytes, which are white blood cells that play a significant role in the body's immune response. These lymphocytes are found in a variety of states, from those that are free and able to move within the lymphatic system to those that are in various stages of development within the lymphoid tissue.

Function

The primary function of MALT is to facilitate the immune response within the mucosa of the body. It does this by producing lymphocytes that can respond to pathogens that may be present in the mucosal tissue. These lymphocytes can then either directly attack the pathogen, or they can produce antibodies that can neutralize the pathogen.

Clinical significance

MALT is the site of origin of MALT lymphoma, a form of lymphoma involving the mucosa-associated lymphoid tissue. MALT lymphomas can occur in any mucosal site, but the stomach is the most commonly affected organ.

See also

• Gut-associated lymphoid tissue
• Bronchus-associated lymphoid tissue
• Nasal-associated lymphoid tissue

References

MALT Resources
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