MAP2K7

MAP2K7 is a human gene that encodes for the protein Mitogen-activated protein kinase kinase 7 (MAP2K7). This protein is a member of the MAP kinase kinase family and plays a crucial role in the MAP kinase signal transduction pathway.

Function

The MAP2K7 gene is involved in the c-Jun N-terminal kinases (JNK) signaling pathway. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically interacts with and activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2, MAP3K3/MEKK5, and MAP4K2/GCK.

Clinical significance

Mutations in the MAP2K7 gene have been associated with various diseases, including cancer, neurodegenerative diseases, and autoimmune diseases. In cancer, alterations in this gene are frequently found in melanoma, colon cancer, and lung cancer. In neurodegenerative diseases, mutations in MAP2K7 have been linked to Alzheimer's disease and Parkinson's disease. In autoimmune diseases, this gene has been implicated in rheumatoid arthritis and systemic lupus erythematosus.

Research

Research on the MAP2K7 gene and its encoded protein is ongoing, with studies focusing on its role in disease development and potential as a therapeutic target. For example, inhibitors of MAP2K7 are being investigated for their potential use in treating cancer and inflammatory diseases.

See also

• Mitogen-activated protein kinase
• c-Jun N-terminal kinases
• MAP kinase signal transduction pathway