MAP3K1

MAP3K1 (Mitogen-Activated Protein Kinase Kinase Kinase 1), also known as MEKK1, is a gene that encodes a member of the serine/threonine protein kinase family. This kinase is regulated through direct phosphorylation by MAPK kinases as well as by autophosphorylation. From the nucleus, it translocates to the cytoplasm in the presence of high cellular stress.

Function

The MAP3K1 gene provides instructions for making a protein that is involved in transmitting chemical signals within cells (intracellular signaling). This protein is part of several signaling pathways, including those that regulate the activity of certain genes and influence cell growth and division (proliferation), the process by which cells mature to carry out specific functions (differentiation), cell movement (migration), and the self-destruction of cells (apoptosis).

Clinical significance

Mutations in the MAP3K1 gene have been associated with cancer, specifically breast cancer. These mutations are believed to disrupt the normal function of the MAP3K1 protein, leading to uncontrolled cell growth and division and the formation of a tumor.

See also

• Mitogen-activated protein kinase
• MAP kinase kinase kinase

References

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