MAS1

MAS1 is a gene that encodes the protein MAS1 receptor, also known as the angiotensin (1-7) receptor. This receptor is a part of the renin-angiotensin system, which plays a crucial role in regulating blood pressure and fluid balance in the body.

Function

The MAS1 receptor is a G-protein coupled receptor that binds the peptide hormone angiotensin (1-7). This binding initiates a cascade of intracellular events that ultimately lead to the dilation of blood vessels, reduction of inflammation, and protection of organs such as the heart and kidneys from damage.

Clinical Significance

Mutations in the MAS1 gene can lead to a variety of health conditions. For instance, a lack of functional MAS1 receptors can result in hypertension, or high blood pressure. Conversely, overactivity of the MAS1 receptor can lead to hypotension, or low blood pressure.

Research has also suggested a link between the MAS1 receptor and cancer. Some studies have found that the receptor can promote the growth and spread of cancer cells, while others have found that it can inhibit these processes.

See Also

• Renin-angiotensin system
• Hypertension
• Cancer