MDBZ
MDBZ is a benzodiazepine derivative that is a potent anxiolytic and sedative. It is structurally related to diazepam and midazolam, but has a unique pharmacological profile that distinguishes it from other benzodiazepines.
Chemistry[edit | edit source]
MDBZ is a benzodiazepine, a class of drugs that are derivatives of 1,4-benzodiazepine. It has a seven-membered diazepine ring fused to a benzene ring. MDBZ is a 1,4-benzodiazepine, which means that the seven-membered ring is fused between the second and fifth carbons of the benzene ring.
Pharmacology[edit | edit source]
Like other benzodiazepines, MDBZ acts as a positive allosteric modulator of the GABA_A receptor, enhancing the effects of the neurotransmitter GABA. This results in increased inhibitory effects in the brain, leading to sedation, anxiolysis, muscle relaxation, and anticonvulsant effects.
MDBZ has a unique pharmacological profile compared to other benzodiazepines. It has a high affinity for the α1 and α5 subunits of the GABA_A receptor, which are associated with sedation and memory effects, respectively. This may explain the potent sedative effects of MDBZ and its potential for causing anterograde amnesia.
Clinical Use[edit | edit source]
MDBZ is not currently approved for medical use in any country. However, it has been studied in preclinical trials for its potential use in the treatment of anxiety disorders, insomnia, and seizure disorders. Its potent sedative effects and potential for causing anterograde amnesia may limit its clinical utility.
See Also[edit | edit source]
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Benzodiazipines[edit source]
- Alprazolam
- Chlordiazepoxide
- Diazepam (Oral)
- Estazolam
- Flurazepam
- Lorazepam
- Midazolam
- Oxazepam
- Quazepam
- Temazepam
- Triazolam
Anticonvulsants Drugs[edit source]
Drug class for MDBZ[edit source]
Sedatives and Hypnotics[edit source]
- Herbals
- Chamomile (Matricaria recutita)
- Hops (Humulus lupulus)
- Lavender (Lavandula angustifolia)
- Passionflower (Passiflora incarnata)
- Valerian (Valeriana officinalis)
- Melatonin and its Analogues
Miscellaneous Agents
- Buspirone
- Chloral hydrate
- Doxepin
- Meprobamate
- Sodium Oxybate (Narcolepsy Agent)
- Suvorexant
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Contributors: Prab R. Tumpati, MD
