MDBZ

MDBZ

MDBZ is a benzodiazepine derivative that is a potent anxiolytic and sedative. It is structurally related to diazepam and midazolam, but has a unique pharmacological profile that distinguishes it from other benzodiazepines.

Chemistry

MDBZ is a benzodiazepine, a class of drugs that are derivatives of 1,4-benzodiazepine. It has a seven-membered diazepine ring fused to a benzene ring. MDBZ is a 1,4-benzodiazepine, which means that the seven-membered ring is fused between the second and fifth carbons of the benzene ring.

Pharmacology

Like other benzodiazepines, MDBZ acts as a positive allosteric modulator of the GABA_A receptor, enhancing the effects of the neurotransmitter GABA. This results in increased inhibitory effects in the brain, leading to sedation, anxiolysis, muscle relaxation, and anticonvulsant effects.

MDBZ has a unique pharmacological profile compared to other benzodiazepines. It has a high affinity for the α1 and α5 subunits of the GABA_A receptor, which are associated with sedation and memory effects, respectively. This may explain the potent sedative effects of MDBZ and its potential for causing anterograde amnesia.

Clinical Use

MDBZ is not currently approved for medical use in any country. However, it has been studied in preclinical trials for its potential use in the treatment of anxiety disorders, insomnia, and seizure disorders. Its potent sedative effects and potential for causing anterograde amnesia may limit its clinical utility.

See Also

• Benzodiazepine
• GABA_A receptor
• Anxiolytic
• Sedative

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Benzodiazipines

• Alprazolam
• Chlordiazepoxide
• Diazepam (Oral)
• Estazolam
• Flurazepam
• Lorazepam
• Midazolam
• Oxazepam
• Quazepam
• Temazepam
• Triazolam

Anticonvulsants Drugs

• Clobazam
• Clonazepam
• Clorazepate
• Diazepam (Intravenous)

Drug class for MDBZ

Anticonvulsants, and Benzodiazepines]

Sedatives and Hypnotics

• Antihistamines
• Diphenhydramine
• Doxylamine
• Hydroxyzine

• Barbiturates
  • Amobarbital
  • Butabarbital
  • Phenobarbital
  • Secobarbital

• Benzodiazepines
  • Diazepam
  • Estazolam
  • Flurazepam
  • Quazepam
  • Temazepam
  • Triazolam

• Benzodiazepine Receptor Agonists
  • Eszopiclone
  • Zaleplon
  • Zolpidem

• Herbals
  • Chamomile (Matricaria recutita)
  • Hops (Humulus lupulus)
  • Lavender (Lavandula angustifolia)
  • Passionflower (Passiflora incarnata)
  • Valerian (Valeriana officinalis)

• Melatonin and its Analogues
  • Melatonin
  • Ramelteon
  • Tasimelteon

Miscellaneous Agents

• • Buspirone
  • Chloral hydrate
  • Doxepin
  • Meprobamate
  • Sodium Oxybate (Narcolepsy Agent)
  • Suvorexant