MED18

MED18 is a gene that encodes a component of the Mediator complex in humans. The Mediator complex is a multi-protein complex that functions as a transcriptional coactivator in all eukaryotes. It plays a key role in the regulation of RNA polymerase II-dependent gene transcription.

Function

MED18, also known as Mediator complex subunit 18, is a part of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. MED18 functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. The Mediator complex, and therefore MED18, is required for the transcription of most genes.

Structure

The MED18 gene is located on the chromosome 6 (6q23.3) and spans 15.54 kb. The gene includes 9 exons and encodes a 187-amino acid protein. The protein is a part of the Mediator complex, which is composed of 26 to 30 subunits and includes a head, middle, tail, and a kinase module.

Clinical significance

Mutations in the MED18 gene have been associated with various diseases. For example, a study found that MED18 is overexpressed in breast cancer tissues and can promote cell proliferation and tumor growth. Therefore, MED18 could potentially serve as a therapeutic target for breast cancer.

The Mediator complex. MED18 is a component of this complex.

See also

• Mediator complex
• Transcription (genetics)
• RNA polymerase II