MIR106A

MIR106A is a microRNA that in humans is encoded by the MIR106A gene. MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression post-transcriptionally, playing a key role in various biological and pathological processes.

Function

MIR106A is part of the miR-106a~363 cluster, which is located in the X chromosome and includes six miRNAs. This cluster is highly conserved in vertebrates, suggesting a significant functional importance. MIR106A has been implicated in a variety of biological processes, including cell proliferation, apoptosis, and differentiation. It acts by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or translational repression.

Clinical significance

Alterations in the expression of MIR106A have been associated with several types of cancer, including prostate cancer, colorectal cancer, and hepatocellular carcinoma. Overexpression of MIR106A has been shown to promote cell proliferation and inhibit apoptosis, suggesting a potential role in tumorigenesis. In addition, MIR106A may serve as a potential biomarker for the diagnosis and prognosis of certain cancers.

Research

Research into the role of MIR106A in disease processes is ongoing. Understanding the precise mechanisms by which MIR106A contributes to disease may lead to the development of novel therapeutic strategies.

See also

• MicroRNA
• Gene expression
• Apoptosis
• Cell proliferation