MIR141
MIR141 is a microRNA that in humans is encoded by the MIR141 gene. It is a small non-coding RNA molecule that functions in RNA silencing and post-transcriptional regulation of gene expression.
Function[edit | edit source]
MIR141 is part of the miR-200 family, which is known for its role in inhibiting epithelial to mesenchymal transition (EMT), a process that is crucial for embryonic development, cancer progression, and metastasis. By targeting the transcriptional repressors of E-cadherin, ZEB1 and ZEB2, miR-141 helps to maintain the epithelial phenotype and prevent EMT.
Clinical significance[edit | edit source]
Alterations in the expression of this microRNA are associated with various types of cancers, including ovarian cancer, colorectal cancer, and hepatocellular carcinoma. In ovarian cancer, miR-141 is significantly downregulated, and its low expression is associated with poor prognosis. In colorectal cancer, miR-141 suppresses tumor growth and metastasis by targeting the MAP4K4 gene. In hepatocellular carcinoma, miR-141 is also downregulated, and its overexpression inhibits cell proliferation and induces apoptosis.
See also[edit | edit source]
- MicroRNA
- miR-200 family
- Epithelial to mesenchymal transition
- Ovarian cancer
- Colorectal cancer
- Hepatocellular carcinoma
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD