MIR194-1

MIR194-1 is a microRNA that in humans is encoded by the MIR194-1 gene. MicroRNAs (miRNAs) are small non-coding RNA molecules, primarily involved in the regulation of gene expression. They have been implicated in a variety of biological processes and diseases, including cancer.

Function

MIR194-1 is a member of the miR-194 family of microRNAs. It is involved in the regulation of gene expression by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or translational repression. This gene is located in a region of chromosome 1 that is associated with genetic susceptibility to colorectal cancer.

Clinical significance

MIR194-1 has been implicated in several types of cancer, including colorectal cancer, hepatocellular carcinoma, and gastric cancer. It acts as a tumor suppressor by inhibiting cell proliferation, migration, and invasion, and promoting apoptosis. In colorectal cancer, MIR194-1 is often downregulated, and its expression level is inversely correlated with tumor stage and prognosis.

Research

Research into the role of MIR194-1 in cancer is ongoing. Studies have shown that it targets several oncogenes, including RAC1, CCND1, and BCL2. Further understanding of the mechanisms by which MIR194-1 regulates these genes could lead to new therapeutic strategies for cancer.

See also

• MicroRNA
• Colorectal cancer
• Hepatocellular carcinoma
• Gastric cancer