MK-571

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MK-571 is a chemical compound that acts as a potent and selective antagonist of the leukotriene D4 receptor (also known as the CysLT1 receptor). It is primarily used in scientific research to study the role of leukotrienes in various physiological and pathological processes.

Mechanism of Action

MK-571 functions by inhibiting the binding of leukotriene D4 (LTD4) to its receptor, thereby blocking the downstream signaling pathways that lead to inflammation and bronchoconstriction. This makes it a valuable tool in the study of asthma and other inflammatory diseases where leukotrienes play a significant role.

Applications in Research

MK-571 is widely used in pharmacological studies to investigate the role of leukotrienes in various conditions, including:

• Asthma: By blocking leukotriene receptors, MK-571 helps researchers understand the contribution of leukotrienes to airway inflammation and hyperresponsiveness.
• Allergic rhinitis: Studies using MK-571 can elucidate the role of leukotrienes in nasal inflammation and congestion.
• Cardiovascular diseases: Research has explored the involvement of leukotrienes in atherosclerosis and other cardiovascular conditions using MK-571.

Pharmacokinetics

While MK-571 is not used clinically, its pharmacokinetic properties have been studied in animal models. It is known to have a high affinity for the CysLT1 receptor and a relatively long half-life, making it suitable for in vitro and in vivo studies.

Safety and Handling

As with many research chemicals, MK-571 should be handled with care. Appropriate safety measures, including the use of personal protective equipment and working in a well-ventilated area, are recommended to minimize exposure.

Also see

• Leukotriene receptor antagonist
• Cysteinyl leukotriene receptor
• Montelukast
• Zafirlukast