ML-154

ML-154 is a chemical compound that is used in the field of pharmacology. It is a potent and selective agonist for the neuropeptide receptor neurotensin receptor 1 (NTSR1).

Chemistry

ML-154 is a small molecule that is structurally distinct from the natural ligand neurotensin. It has a high affinity for NTSR1 and is able to activate the receptor with a similar potency to neurotensin. The exact chemical structure of ML-154 is proprietary information and is not publicly available.

Pharmacology

ML-154 is a potent and selective agonist for NTSR1, a G-protein coupled receptor that is widely expressed in the central nervous system and peripheral tissues. Activation of NTSR1 by ML-154 leads to a variety of biological responses, including the release of neurotransmitters, modulation of ion channels, and regulation of cell proliferation and apoptosis.

Therapeutic Potential

Due to its potent and selective activity at NTSR1, ML-154 has potential therapeutic applications in a variety of neurological disorders, including schizophrenia, Parkinson's disease, and pain. It may also have potential in the treatment of cancer, as NTSR1 is overexpressed in several types of cancer and its activation has been shown to inhibit tumor growth.

Research

Research on ML-154 is still in the early stages, and much of the work has been conducted in animal models. Further research is needed to fully understand the pharmacological properties of ML-154 and its potential therapeutic applications.

See Also

• Neurotensin
• Neurotensin receptor 1
• Agonist
• Pharmacology

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