MMP27
MMP27 or Matrix Metallopeptidase 27 is a protein that in humans is encoded by the MMP27 gene. This protein is part of the matrix metalloproteinase (MMP) family, which are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis.
Function[edit | edit source]
MMP27 is a member of the matrix metalloproteinase (MMP) family, which are proteolytic enzymes capable of degrading connective tissue components. The MMPs are synthesized as preproproteins, and most of them are secreted from the cells as proproteins. Once activated, their proteolytic activity is regulated by endogenous inhibitors, tissue inhibitors of metalloproteinases (TIMPs).
Clinical significance[edit | edit source]
MMP27 has been implicated in a variety of disease processes, including cancer, arthritis, and cardiovascular disease. In cancer, MMP27 may play a role in tumor growth and metastasis. In arthritis, MMP27 may contribute to the breakdown of cartilage. In cardiovascular disease, MMP27 may be involved in the remodeling of blood vessels.
See also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
