MXD4

MXD4 or Max dimerization protein 4 is a protein that in humans is encoded by the MXD4 gene. This protein is a member of the MYC/MAX/MXD1 network, a large group of transcription factors involved in cell cycle regulation, cellular differentiation, and apoptosis.

Function

MXD4 is a member of the MYC/MAX/MXD1 network. This network is a group of transcription factors that interact to regulate gene expression, particularly genes involved in cell cycle control and cellular differentiation. MXD4, like other members of this network, can form heterodimers with MAX, another protein in the network, and these heterodimers can bind to specific DNA sequences to regulate gene expression.

Clinical significance

Alterations in the MYC/MAX/MXD1 network, including changes in MXD4, have been implicated in a variety of cancers. For example, overexpression of MXD4 has been observed in some types of leukemia and lymphoma, suggesting that it may play a role in the development of these diseases.

See also

• MYC (gene)
• MAX (gene)
• MXD1
• Transcription factor

External links

• MXD4 at the National Center for Biotechnology Information