MXI1
MXI1 is a gene that encodes a protein in humans. This protein is a member of the Myc family of transcription factors and has a role in cell cycle regulation, apoptosis, and cellular differentiation.
Function[edit | edit source]
The MXI1 protein is a transcriptional repressor. It binds to E-box DNA sequences (5'-CANNTG-3'). This protein interacts with histone deacetylases and inhibits the transcriptional activity of Myc, which controls cell cycle progression and proliferation.
Clinical Significance[edit | edit source]
Alterations in the MXI1 gene have been associated with several types of cancer, including prostate cancer, breast cancer, and neuroblastoma. Overexpression of MXI1 can inhibit Myc-mediated transformation and apoptosis, suggesting a potential role for MXI1 in cancer therapy.
Interactions[edit | edit source]
MXI1 has been shown to interact with:
See Also[edit | edit source]
References[edit | edit source]
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Contributors: Prab R. Tumpati, MD
