Mafenide acetate

Mafenide Acetate is a sulfonamide derivative that is used as a topical agent in the treatment of burns. It is a white crystalline powder that is soluble in water and has a strong, characteristic odor. Mafenide Acetate is known for its broad-spectrum antibacterial activity and its ability to penetrate eschar and necrotic tissue.

Pharmacology

Mafenide Acetate works by inhibiting the enzyme dihydropteroate synthase, which is necessary for the synthesis of folic acid. This prevents the bacteria from producing folic acid, which is essential for their growth and reproduction. Mafenide Acetate is effective against many types of bacteria, including both Gram-positive and Gram-negative organisms.

Uses

Mafenide Acetate is primarily used in the treatment of burns, particularly second and third degree burns. It is applied topically to the burn area to prevent infection and promote healing. Mafenide Acetate is also used in the treatment of other skin conditions, such as wound infections and ulcers.

Side Effects

The most common side effects of Mafenide Acetate include skin irritation, burning sensation, and pain at the application site. In rare cases, it can cause serious side effects such as allergic reactions, metabolic acidosis, and hemolytic anemia.

Precautions

Patients with known hypersensitivity to sulfonamides should not use Mafenide Acetate. It should also be used with caution in patients with impaired renal function or pre-existing metabolic acidosis.

See Also

• Sulfonamides
• Burn
• Topical medication