Mafodotin

Mafodotin is a type of antibody-drug conjugate (ADC) used in the treatment of various types of cancer. It is a synthetic compound that combines an antibody with a potent cytotoxic agent, allowing for targeted delivery of the cytotoxic agent to cancer cells.

Mechanism of Action

Mafodotin works by binding to a specific protein on the surface of cancer cells. Once bound, the ADC is internalized by the cell, where the cytotoxic agent is released. This agent then interferes with the cell's ability to divide and grow, leading to cell death.

Uses

Mafodotin is used in the treatment of several types of cancer, including non-Hodgkin lymphoma and breast cancer. It is often used in combination with other chemotherapy drugs to increase its effectiveness.

Side Effects

Like all chemotherapy drugs, mafodotin can cause side effects. These can include nausea, vomiting, hair loss, and fatigue. More serious side effects can include neutropenia, a condition characterized by low levels of white blood cells, and peripheral neuropathy, a condition characterized by damage to the nerves in the hands and feet.

Research

Research is ongoing into the use of mafodotin in the treatment of other types of cancer. Early results have been promising, but more research is needed to fully understand the potential benefits and risks of this treatment.