Malpighian layer

Malpighian layer or stratum malpighii is the layer of the epidermis that lies between the stratum granulosum and the stratum basale. Named after the Italian biologist Marcello Malpighi, it is responsible for the generation of new cells in the skin.

Structure

The Malpighian layer is composed of two parts: the stratum spinosum (or spiny layer) and the stratum basale (or basal layer). The stratum spinosum is a multi-layered arrangement of cuboidal cells, while the stratum basale is a single layer of columnar cells directly above the dermis.

Function

The primary function of the Malpighian layer is to produce new keratinocytes, which are the predominant cell type in the epidermis. These cells migrate upwards to the skin surface, replacing cells that are shed. This process is known as keratinization and is vital for maintaining the integrity and function of the skin.

Clinical significance

Abnormalities in the Malpighian layer can lead to a variety of skin conditions. For example, psoriasis is characterized by an increased rate of keratinocyte production in the Malpighian layer, leading to thickened, scaly skin. In contrast, skin cancer can arise from mutations in the DNA of keratinocytes in the Malpighian layer.

See also

• Epidermis (skin)
• Keratinocyte
• Skin cancer
• Psoriasis

Malpighian layer Resources
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