Meclinertant

Meclinertant (also known as SR-48692) is a drug which acts as a selective, non-peptide antagonist at the Neurotensin receptor NTS1, and was the first non-peptide antagonist developed for this receptor. It is used in scientific research to explore the interaction between neurotensin and other neurotransmitters in the brain, and produces a range of effects such as reducing dopamine release and altering the function of certain types of potassium channels.

Pharmacology

Meclinertant is a non-peptide antagonist of the neurotensin receptor NTS1. Neurotensin is a peptide that is found in the brain and the gut, and it has a variety of physiological effects. Meclinertant blocks the action of neurotensin at the NTS1 receptor, which can alter the release of dopamine and the function of potassium channels.

Uses in Research

Meclinertant is used in scientific research to study the role of neurotensin and the NTS1 receptor in the brain. It has been used in studies investigating the role of neurotensin in schizophrenia, Parkinson's disease, and drug addiction. By blocking the action of neurotensin, researchers can better understand how this peptide contributes to these and other conditions.

Side Effects and Safety

As a research tool, meclinertant is not typically used in humans, so its safety profile and potential side effects are not well known. However, in animal studies, it has been shown to cause a decrease in locomotor activity and to produce hypothermia.

See Also

• Neurotensin
• Neurotensin receptor
• Dopamine
• Potassium channel

References

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