Megesterol

Megestrol is a progestin type of medication used primarily to treat breast cancer and endometrial cancer. It is also used to increase appetite and cause weight gain in people with severe malnutrition or unexplained, significant weight loss. This medication is available in both tablet and liquid forms.

Medical Uses[edit | edit source]

Megestrol is used to treat advanced breast cancer and endometrial cancer. It works by interfering with the hormone balance within the body, which can slow the growth of certain types of cancer cells. In addition, it is used to stimulate appetite and weight gain in individuals suffering from severe malnutrition or unexplained weight loss, often in the context of cancer or AIDS.

Side Effects[edit | edit source]

Common side effects of megestrol include weight gain, upset stomach, gas, trouble sleeping, rash, reduced sexual desire, impotence, and difficulty having an orgasm. Serious side effects may include blood clots, heart failure, and lung disease.

Pharmacology[edit | edit source]

Megestrol is a synthetic progestin. It binds to the progesterone receptor, resulting in a variety of effects. In terms of its use for appetite stimulation, the exact mechanism is unclear, but it may involve actions in the hypothalamus and the liver.

History[edit | edit source]

Megestrol was approved for medical use in the United States in 1971. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

References[edit | edit source]

External Links[edit | edit source]

Megesterol Resources
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