Megesterol

Megestrol is a progestin type of medication used primarily to treat breast cancer and endometrial cancer. It is also used to increase appetite and cause weight gain in people with severe malnutrition or unexplained, significant weight loss. This medication is available in both tablet and liquid forms.

Medical Uses

Megestrol is used to treat advanced breast cancer and endometrial cancer. It works by interfering with the hormone balance within the body, which can slow the growth of certain types of cancer cells. In addition, it is used to stimulate appetite and weight gain in individuals suffering from severe malnutrition or unexplained weight loss, often in the context of cancer or AIDS.

Side Effects

Common side effects of megestrol include weight gain, upset stomach, gas, trouble sleeping, rash, reduced sexual desire, impotence, and difficulty having an orgasm. Serious side effects may include blood clots, heart failure, and lung disease.

Pharmacology

Megestrol is a synthetic progestin. It binds to the progesterone receptor, resulting in a variety of effects. In terms of its use for appetite stimulation, the exact mechanism is unclear, but it may involve actions in the hypothalamus and the liver.

History

Megestrol was approved for medical use in the United States in 1971. It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.

See Also

• List of progestogens
• List of antineoplastic and immunomodulating agents

External Links

• Megestrol (Professional Patient Advice) - Drugs.com
• Megestrol - National Cancer Institute

Megesterol Resources
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