Megestrol

Megestrol is a progestin type of hormone that is primarily used in the treatment of breast cancer and endometrial cancer. It is also used to stimulate appetite in people with severe appetite loss.

Medical Uses

Megestrol is used in the treatment of advanced breast cancer and endometrial cancer. It is also used to stimulate appetite in people with severe appetite loss, such as those with AIDS or cancer.

Side Effects

Common side effects of megestrol include weight gain, edema, thromboembolism, and hyperglycemia. Less common side effects include nausea, diarrhea, and impotence.

Pharmacology

Megestrol is a synthetic progestin that works by binding to and activating the progesterone receptor. This leads to changes in gene expression and cell cycle regulation, which can inhibit the growth of certain types of cancer cells.

History

Megestrol was first synthesized in 1959 and was approved for medical use in the United States in 1971. It is available as a generic medication.

See Also

• List of progestogens
• List of antineoplastic and immunomodulating agents

Megestrol Resources
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