Meglumine antimoniate

Meglumine antimoniate is a medication used in the treatment of leishmaniasis. It is administered by injection.

Medical uses

Meglumine antimoniate is used to treat cutaneous leishmaniasis, mucocutaneous leishmaniasis, and visceral leishmaniasis. It is the first-line treatment for these conditions in many parts of the world.

Side effects

Common side effects of meglumine antimoniate include pain at the injection site, fever, nausea, and vomiting. More serious side effects can include kidney damage and abnormal heart rhythms.

Mechanism of action

Meglumine antimoniate is an antimonial drug. It is thought to work by inhibiting the enzyme trypanothione reductase, which is essential for the survival of the parasite that causes leishmaniasis.

History

Meglumine antimoniate was first synthesized in the 1940s. It has been on the World Health Organization's List of Essential Medicines since the list was first published in 1977.

See also

• Leishmaniasis
• Antimonial drug
• World Health Organization's List of Essential Medicines

Meglumine antimoniate Resources
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