Mephentermine sulfate

Mephentermine sulfate is a cardiac stimulant that belongs to the pharmacological class of sympathomimetic amines. It is primarily used in the treatment of hypotension and is often administered to patients undergoing surgery to maintain blood pressure.

Pharmacology

Mephentermine sulfate acts by stimulating adrenergic receptors, specifically the alpha-adrenergic receptors. This stimulation leads to an increase in cardiac output and a rise in blood pressure. The drug also has a mild bronchodilator effect, which can be beneficial in certain clinical situations.

Clinical Use

The primary use of mephentermine sulfate is in the management of hypotension, particularly during surgery. It is also used in the treatment of shock and heart failure. In some cases, it may be used to treat asthma due to its bronchodilator effects.

Side Effects

Like other sympathomimetic amines, mephentermine sulfate can cause a range of side effects. These may include palpitations, tachycardia, anxiety, tremors, and headache. In rare cases, it can cause severe hypertension.

Contraindications

Mephentermine sulfate is contraindicated in patients with hypersensitivity to sympathomimetic amines. It should also be used with caution in patients with coronary artery disease, hyperthyroidism, and glaucoma.

See Also

• Sympathomimetic amines
• Hypotension
• Adrenergic receptors

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