Meprodine

Meprodine is a synthetic opioid analgesic drug, which is a member of the pethidine (meperidine) class (itself a part of the larger opioid class of drugs). It was developed in the mid-20th century and has been used for the treatment of both acute and chronic pain.

Chemistry

Meprodine is a synthetic opioid, meaning it is not derived from naturally occurring opium alkaloids. It is structurally related to pethidine, with the key difference being the replacement of the carbonyl group with a methylene bridge. This modification results in a compound with increased potency and duration of action compared to pethidine.

Pharmacology

Meprodine acts primarily as a mu-opioid receptor agonist. This receptor subtype is responsible for the analgesic effects of opioids. Meprodine has a high affinity for the mu-opioid receptor, resulting in potent analgesic effects. It also has a lower affinity for the kappa-opioid receptor and delta-opioid receptor, which may contribute to its analgesic effects and side effect profile.

Clinical Use

Meprodine is used for the treatment of moderate to severe pain. It can be used for both acute pain, such as post-operative pain, and chronic pain conditions. It is typically administered orally, but can also be given by intramuscular or intravenous injection in a hospital setting.

Side Effects

Like all opioids, Meprodine has a range of side effects. These can include nausea, vomiting, constipation, and drowsiness. More serious side effects can include respiratory depression, which can be life-threatening if not managed properly. As with all opioids, there is also a risk of dependence and addiction with long-term use.

See Also

• Opioid
• Pethidine
• Mu-opioid receptor
• Kappa-opioid receptor
• Delta-opioid receptor