Metastron
A radiopharmaceutical used in the treatment of bone pain in cancer patients
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Metastron is a radiopharmaceutical used primarily for the treatment of bone pain associated with cancer that has metastasized to the bone. It contains the radioactive isotope strontium-89, which mimics calcium and is preferentially taken up by bone tissue, particularly in areas with increased bone turnover such as metastatic lesions.
Mechanism of Action[edit | edit source]
Metastron works by delivering targeted radiation therapy to bone metastases. The strontium-89 isotope emits beta particles, which have a short range in biological tissues. This allows for localized radiation therapy, minimizing damage to surrounding healthy tissues. The beta particles emitted by strontium-89 cause damage to the DNA of cancer cells, leading to cell death and a reduction in tumor size, which alleviates pain.
Clinical Use[edit | edit source]
Metastron is indicated for the relief of bone pain in patients with painful skeletal metastases. It is particularly used in cases where the cancer has spread to the bones, such as in prostate cancer and breast cancer. The treatment is administered intravenously, and the effects can last for several months, providing significant pain relief and improving the quality of life for patients.
Side Effects[edit | edit source]
Common side effects of Metastron include a temporary increase in bone pain, known as a "flare" reaction, which typically occurs within the first few days after administration. Other side effects may include a decrease in blood cell counts, particularly white blood cells and platelets, due to the radiation effect on the bone marrow.
Contraindications[edit | edit source]
Metastron is contraindicated in patients with severely compromised bone marrow function, as the treatment can further suppress bone marrow activity. It is also not recommended for use in pregnant or breastfeeding women due to the potential risk of radiation exposure to the fetus or infant.
Also see[edit | edit source]
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