Methoxyhydroxyphenylglycol

Methoxyhydroxyphenylglycol (MHPG) is a metabolite of the neurotransmitter norepinephrine (NE). It is primarily found in the central nervous system (CNS) and is a significant indicator of norepinephrine activity within the body.

Structure and Function

MHPG is a catecholamine metabolite, meaning it is produced during the breakdown of catecholamines such as norepinephrine. The structure of MHPG includes a phenol group, which is a ring of carbon atoms with a hydroxyl (-OH) group attached. This structure allows MHPG to interact with various enzymes and receptors within the body.

The primary function of MHPG is to serve as a marker for norepinephrine activity. Because it is produced when norepinephrine is broken down, levels of MHPG in the body can indicate how much norepinephrine is being used. This can be particularly useful in diagnosing and monitoring certain medical conditions, such as depression and anxiety disorders.

Clinical Significance

MHPG levels can be measured in the urine, blood, and cerebrospinal fluid (CSF) to assess norepinephrine activity. Elevated levels of MHPG may indicate increased norepinephrine activity, which can be associated with conditions such as mania, schizophrenia, and certain types of heart disease. Conversely, decreased levels of MHPG may suggest reduced norepinephrine activity, which can be seen in conditions like depression.

In addition to its role in diagnosing and monitoring disease, MHPG may also have potential therapeutic applications. For example, some research suggests that manipulating MHPG levels could potentially be used to treat conditions associated with abnormal norepinephrine activity.

See Also

• Norepinephrine
• Catecholamine
• Neurotransmitter
• Metabolite