3-Methoxy-4-hydroxyphenylglycol

A metabolite of norepinephrine

Pathway of norepinephrine metabolism

3-Methoxy-4-hydroxyphenylglycol (MHPG) is a metabolite of the neurotransmitter norepinephrine. It is primarily found in the cerebrospinal fluid, blood plasma, and urine. MHPG is used as a marker for the activity of the noradrenergic system in the central nervous system.

Biochemistry

MHPG is produced through the metabolic breakdown of norepinephrine. The process involves several enzymatic steps, including the action of monoamine oxidase and catechol-O-methyltransferase. The resulting compound, MHPG, is then excreted from the body.

Clinical significance

The levels of MHPG in the body can be indicative of various psychiatric and neurological disorders. Elevated levels of MHPG have been associated with conditions such as depression, anxiety disorders, and bipolar disorder. Conversely, low levels may be observed in certain types of schizophrenia.

Measurement

MHPG levels can be measured in cerebrospinal fluid, plasma, and urine samples. These measurements are often used in research settings to study the function of the noradrenergic system and its role in various mental health conditions.

Related pages

• Norepinephrine
• Monoamine oxidase
• Catechol-O-methyltransferase
• Noradrenergic system