Methyl phenylacetate

Methyl phenylacetate is an organic compound with the chemical formula C₉H₁₀O₂. It is an ester formed from the condensation of phenylacetic acid and methanol. This compound is significant in the field of organic chemistry and is used in various applications, including as a flavoring agent and in the synthesis of other chemicals.

Properties

Methyl phenylacetate is a clear, colorless liquid at room temperature. It has a characteristic sweet, honey-like odor, which makes it valuable in the flavor and fragrance industries. The compound has a boiling point of approximately 218°C and a molecular weight of 150.17 g/mol. It is slightly soluble in water but highly soluble in organic solvents such as ethanol, diethyl ether, and benzene.

Synthesis

The synthesis of methyl phenylacetate typically involves the esterification of phenylacetic acid with methanol. This reaction is often catalyzed by an acid, such as sulfuric acid or hydrochloric acid, under reflux conditions. The process can be represented by the following chemical equation:

Phenylacetic acid + Methanol → Methyl phenylacetate + Water

Applications

Methyl phenylacetate has a wide range of applications due to its pleasant aroma and versatility as a chemical intermediate. In the flavor and fragrance industry, it is used to impart sweet, floral, and honey-like notes to various products, including perfumes, cosmetics, and food items. Additionally, it serves as a starting material in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds.

Safety and Toxicology

Like many organic esters, methyl phenylacetate is generally considered to have low toxicity. However, it should be handled with care, as it can cause irritation to the skin, eyes, and respiratory system upon exposure. Proper personal protective equipment, such as gloves and goggles, should be worn when handling this chemical. It is also important to work in a well-ventilated area or use appropriate engineering controls, such as fume hoods, to minimize exposure.

Environmental Impact

The environmental impact of methyl phenylacetate is relatively low. It is biodegradable and is not known to accumulate in the environment or in living organisms. However, as with all chemicals, it should be disposed of properly to prevent potential harm to the environment.

See Also

• Esterification
• Phenylacetic acid
• Methanol
• Organic chemistry
• Flavor and fragrance industry