Methylazoxymethanol acetate

Methylazoxymethanol acetate

Methylazoxymethanol acetate (MAM) is a potent neurotoxin derived from the plant Cycas revoluta, also known as the sago palm. It is used in scientific research to create animal models of neurological disorders, such as schizophrenia and epilepsy.

Chemistry

Methylazoxymethanol acetate is an ester of methylazoxymethanol (MAM) and acetic acid. The MAM moiety is responsible for the neurotoxic effects of the compound. It is a small, lipophilic molecule that can easily cross the blood-brain barrier.

Mechanism of action

MAM exerts its neurotoxic effects by inhibiting DNA synthesis. It is a potent alkylating agent that forms covalent bonds with DNA, leading to DNA damage and cell death. The compound preferentially targets rapidly dividing cells, such as those in the developing brain.

Use in research

In scientific research, MAM is used to create animal models of neurological disorders. When administered to pregnant animals, it causes selective destruction of neuronal precursors in the offspring, leading to brain abnormalities similar to those seen in human neurological disorders. For example, MAM-treated rats show behavioral and neuroanatomical changes that resemble those in schizophrenia and epilepsy.

Safety

MAM is a potent neurotoxin and a potential carcinogen. It should be handled with care to avoid exposure. Protective clothing, gloves, and eye/face protection should be used when handling the compound.

See also

• Neurotoxin
• Schizophrenia
• Epilepsy
• Cycas revoluta