Methylergonovine

Methylergonovine is a semi-synthetic ergot alkaloid used to prevent or control postpartum hemorrhage (PPH), a condition characterized by excessive bleeding following childbirth. It is also used to treat or prevent bleeding after an abortion.

Pharmacology

Methylergonovine acts on the smooth muscle of the uterus, causing it to contract. It does this by stimulating the receptors for the neurotransmitter serotonin, which is involved in the regulation of smooth muscle contraction. This action helps to reduce bleeding by causing the blood vessels in the uterus to constrict.

Medical Uses

Methylergonovine is primarily used in the prevention and treatment of postpartum hemorrhage. It is administered after the delivery of the placenta to help the uterus contract and reduce bleeding. It can also be used to treat PPH when it occurs.

In addition to its use in obstetrics, methylergonovine can also be used to prevent or treat bleeding following an abortion.

Side Effects

Like all medications, methylergonovine can cause side effects. These can include nausea, vomiting, and abdominal pain. More serious side effects can include high blood pressure, seizures, and heart attack.

Contraindications

Methylergonovine should not be used in patients with hypersensitivity to ergot alkaloids, or in patients with high blood pressure, heart disease, or liver disease. It should also not be used during pregnancy, as it can cause uterine contractions that could lead to miscarriage or premature labor.

See Also

• Ergot Alkaloids
• Postpartum Hemorrhage
• Serotonin