Methylmalonic acid
Methylmalonic acid (MMA) is a dicarboxylic acid that is a vital intermediate in the metabolism of fat and protein. It is a substance that is produced when proteins, specifically those containing the amino acid methionine, are broken down in the body.
Chemistry[edit | edit source]
Methylmalonic acid is a chiral compound with two enantiomers, (R)- and (S)-methylmalonic acid. It is a colorless, crystalline solid that is soluble in water. The chemical formula for methylmalonic acid is C4H6O4.
Biosynthesis[edit | edit source]
Methylmalonic acid is produced in the body during the metabolism of certain amino acids and odd-chain fatty acids. The process begins with the conversion of these substances into propionyl-CoA, which is then converted into methylmalonyl-CoA by the enzyme propionyl-CoA carboxylase. Methylmalonyl-CoA is then converted into succinyl-CoA, a key intermediate in the citric acid cycle, by the enzyme methylmalonyl-CoA mutase.
Clinical significance[edit | edit source]
Elevated levels of methylmalonic acid in the blood, a condition known as methylmalonic acidemia, can be a sign of several different health problems, including vitamin B12 deficiency, kidney disease, and certain genetic disorders. Methylmalonic acidemia is a serious condition that can lead to developmental delays, failure to thrive, and other health problems if not treated promptly.
See also[edit | edit source]
References[edit | edit source]
Search WikiMD
Ad.Tired of being Overweight? Try W8MD's physician weight loss program.
Semaglutide (Ozempic / Wegovy and Tirzepatide (Mounjaro / Zepbound) available.
Advertise on WikiMD
WikiMD's Wellness Encyclopedia |
Let Food Be Thy Medicine Medicine Thy Food - Hippocrates |
Translate this page: - East Asian
中文,
日本,
한국어,
South Asian
हिन्दी,
தமிழ்,
తెలుగు,
Urdu,
ಕನ್ನಡ,
Southeast Asian
Indonesian,
Vietnamese,
Thai,
မြန်မာဘာသာ,
বাংলা
European
español,
Deutsch,
français,
Greek,
português do Brasil,
polski,
română,
русский,
Nederlands,
norsk,
svenska,
suomi,
Italian
Middle Eastern & African
عربى,
Turkish,
Persian,
Hebrew,
Afrikaans,
isiZulu,
Kiswahili,
Other
Bulgarian,
Hungarian,
Czech,
Swedish,
മലയാളം,
मराठी,
ਪੰਜਾਬੀ,
ગુજરાતી,
Portuguese,
Ukrainian
WikiMD is not a substitute for professional medical advice. See full disclaimer.
Credits:Most images are courtesy of Wikimedia commons, and templates Wikipedia, licensed under CC BY SA or similar.
Contributors: Prab R. Tumpati, MD