Mezerein

Mezerein

Mezerein is a phytotoxin and dermatitis-inducing compound found in the Daphne mezereum plant, also known as the February Daphne. It is a member of the daphnane family of diterpenes, a class of organic compounds composed of four isoprene units.

Chemical Structure and Properties

Mezerein is a complex molecule with a unique structure that includes three hydroxyl groups and an ester group. Its chemical formula is C29H38O9. It is a white crystalline solid at room temperature and is soluble in ethanol and methanol, but insoluble in water.

Biological Activity

Mezerein has been found to have several biological activities. It is a potent skin irritant, causing severe dermatitis upon contact. It is also a tumor promoter, meaning it can stimulate the growth of existing cancer cells, but does not initiate cancer itself.

In addition, mezerein has been found to have cytotoxic effects, meaning it can kill cells. This property has led to interest in its potential use as a chemotherapeutic agent. However, its high toxicity and severe side effects have limited its use in this context.

Toxicity

Mezerein is highly toxic and can cause severe skin irritation and gastrointestinal distress if ingested. It is also toxic to many animals, including livestock and pets.

See Also

• Daphne mezereum
• Diterpenes
• Phytotoxin