MicroRNA 148a

MicroRNA 148a (miR-148a) is a small non-coding RNA molecule that regulates gene expression. It is part of the larger family of microRNAs, which are involved in a wide range of biological processes, including development, differentiation, apoptosis, and proliferation.

Function

miR-148a functions by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or translational repression. This process is crucial for the regulation of gene expression. The specific targets of miR-148a vary depending on the cell type and physiological context, but it has been shown to regulate genes involved in processes such as cell proliferation, apoptosis, and immune response.

Role in Disease

Alterations in the expression of miR-148a have been associated with several diseases, including various types of cancer, cardiovascular disease, and autoimmune disease. In many cancers, miR-148a is downregulated, which leads to the overexpression of its target genes and contributes to tumorigenesis. Conversely, in some autoimmune diseases, miR-148a is upregulated, leading to the downregulation of its target genes and contributing to disease pathogenesis.

Therapeutic Potential

Due to its role in disease, miR-148a has been proposed as a potential therapeutic target. Strategies to modulate the expression of miR-148a, such as the use of miRNA mimics or antagomirs, could potentially be used to treat diseases associated with alterations in miR-148a expression.

MicroRNA molecule, of which miR-148a is a member.

See Also

• MicroRNA
• Gene expression
• Non-coding RNA