MicroRNA 203a

MicroRNA 203a (miR-203a) is a small non-coding RNA molecule that plays a significant role in the regulation of gene expression. It is part of the larger family of microRNAs, which are involved in a wide range of biological processes, including cell differentiation, proliferation, and apoptosis.

Function

miR-203a functions by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or translational repression. This mechanism allows miR-203a to regulate the expression of various genes, influencing cellular processes such as cell cycle progression, apoptosis, and cell differentiation.

Role in Disease

miR-203a has been implicated in several diseases, particularly in cancer. Abnormal expression of miR-203a has been observed in various types of cancer, including breast cancer, prostate cancer, and colorectal cancer. In these contexts, miR-203a can act as either a tumor suppressor or an oncogene, depending on the specific genes it targets.

Therapeutic Potential

Due to its role in disease, miR-203a is being investigated for its potential as a therapeutic target. Strategies include the use of miR-203a mimics to restore its expression in cancer cells, or the use of inhibitors to block its function in cases where it acts as an oncogene.

See Also

• MicroRNA
• Gene expression
• Cancer

‎

---

Translate: - East Asian 中文, 日本, 한국어, South Asian हिन्दी, தமிழ், తెలుగు, Urdu, ಕನ್ನಡ, Southeast Asian Indonesian, Vietnamese, Thai, မြန်မာဘာသာ, বাংলা
European español, Deutsch, français, Greek, português do Brasil, polski, română, русский, Nederlands, norsk, svenska, suomi, Italian
Middle Eastern & African عربى, Turkish, Persian, Hebrew, Afrikaans, isiZulu, Kiswahili,
Other Bulgarian, Hungarian, Czech, Swedish, മലയാളം, मराठी, ਪੰਜਾਬੀ, ગુજરાતી, Portuguese, Ukrainian