MicroRNA 210

MicroRNA 210 (miR-210) is a small non-coding RNA molecule that plays a significant role in the regulation of gene expression. It is classified as a microRNA, a category of RNA that does not code for proteins but instead regulates the expression of other genes.

Function

miR-210 is often referred to as the "master hypoxamir" due to its upregulation in response to hypoxia, or low oxygen conditions. It is involved in a variety of biological processes, including cell survival, angiogenesis, and mitochondrial metabolism.

Role in Disease

miR-210 has been implicated in a number of diseases, including cancer, cardiovascular disease, and neurological disorders. In cancer, it is often upregulated and promotes tumor growth and metastasis. In cardiovascular disease, it is involved in the response to hypoxia and ischemia. In neurological disorders, it has been shown to play a role in neuronal survival and response to injury.

Therapeutic Potential

Due to its involvement in a variety of diseases, miR-210 is being investigated as a potential therapeutic target. Strategies include the use of antisense oligonucleotides to inhibit miR-210 expression, as well as the use of miR-210 mimics to enhance its expression in diseases where it is downregulated.

See Also

• MicroRNA
• Hypoxia
• Gene expression

References

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