MicroRNA 93

MicroRNA 93 (miR-93) is a small non-coding RNA molecule that functions in RNA silencing and post-transcriptional regulation of gene expression. It is encoded by the MIR93 gene and is a member of the miR-106b-25 cluster, a group of miRNAs that are often found to be dysregulated in various types of cancer.

Function

miR-93 is involved in the regulation of a wide variety of biological processes, including cell proliferation, cell differentiation, apoptosis, and immune response. It achieves this by binding to the 3' untranslated regions (3' UTRs) of target mRNAs, leading to their degradation or translational repression.

Role in Disease

miR-93 has been implicated in a number of diseases, particularly cancers. It is often overexpressed in tumor tissues and has been associated with poor prognosis in several types of cancer, including breast cancer, colorectal cancer, and hepatocellular carcinoma. In addition, miR-93 has been found to promote tumor growth and metastasis by targeting various tumor suppressor genes.

Therapeutic Potential

Due to its role in disease, miR-93 is being investigated as a potential therapeutic target. Strategies include the use of antagomirs to inhibit miR-93 function, and the development of miR-93 mimics to restore its function in cases where it is downregulated.

See Also

• MicroRNA
• RNA silencing
• Gene expression
• Cancer